Jennifer L. Best-Martin

Senior Counsel


Jennifer L. Best-Martin, Ph.D. is a senior counsel and intellectual property lawyer with Foley & Lardner LLP. Her practice focuses on strategic intellectual property counseling, patent prosecution, invalidity and non-infringement analyses, freedom-to-operate analysis, and intellectual property due diligence in the areas of biotechnology, immunology, microbiology, cellular and molecular biology, and genetics. She has extensive drafting and prosecution experience in life science technologies, including biologics, gene-based therapeutics, oligonucleotide therapeutics, antisense, siRNA, cancer therapeutics, vaccines, and diagnostics. Jennifer is a member of the firm’s Chemical, Biotechnology & Pharmaceutical Practice.

Prior to joining Foley, Jennifer was an associate with Wilson Sonsini Goodrich & Rosati P.C. where she developed her patent prosecution practice, counseled clients on intellectual property strategy, and assisted in due diligence projects for intellectual property acquisitions and company mergers. Jennifer also worked as a technical specialist and patent agent for seven years at various law firms in the San Diego area. In addition, she was a research associate for The Salk Institute for Biological Studies where she received the Ruth L. Kirschstein National Research Service Award and designed and implemented diagnostic screens for small molecule inhibitors.


Jennifer earned her law degree from the University of San Diego School of Law (J.D., 2011) where she received CALI Awards (recognizing highest grade in class) for patent litigation and professional responsibility in the fall of 2009. She was also a member of the San Diego International Law Journal and Phi Delta Phi International Legal Fraternity.

Jennifer received her doctorate of philosophy from Harvard University (Ph.D., 2001) in microbiology and molecular genetics, where she was an Albert J. Ryan Foundation Scholar and received the Yamaguchi Research Award in the Division of Hematology of Children’s Hospital. During this time, she was a doctoral candidate in the Department of Genetics in Children’s Hospital where she designed and implemented cell-based screens and in vitro phosphorylation screens for the identification of kinase regulatory proteins.

Jennifer earned her bachelor’s degree in biology with a concentration in molecular genetics from the University of Rochester (B.S., magna cum laude, 1995).

Admissions and Professional Memberships

Jennifer is admitted to practice in California. She is also registered to practice before the United States Patent and Trademark Office.

Jennifer is a member of the San Diego Intellectual Property Law Association and American Intellectual Property Law Association. She also is an associate member of Athena San Diego and an Alpha Phi Omega National Service Fraternity Alumnus.


  • U.S. Patent No. 6,524,833 - Two sterile-20 kinase-like proteins and methods of use thereof. Zon, L.I., Agarwal, S., Best, J., Vail, B, Granted February 25, 2003.

Selected Publications

  • Zhang, X., Odom, D.T., Koo, S., Conkright, M.D., Canettieri, G., Best, J., Chen H., Jenner, R., Herbolsheimer, E., Jacobsen, E., Kadam, S., Ecker, E., Emerson, B., Hogenesch, J.B., Unterman, T., Young, R.A., and Montminy, M. (2005). “Genomewide Analysis of cAMP-response Element Binding Protein Occupancy, Phosphorylation, and Target Gene Activation in Human Tissues.” Proceedings of the National Academy of Sciences 102(12):4459-64.
  • Best, J.L., Amezcua, C., Mayr, B. Flechner, L., Murawsky, C.M., Emerson, B., Zor, T., Gardner, K., and Montminy, M. (2004). “Identification of Small Molecule Antagonists that Inhibit an Activator: Coactivator Interaction.” Proceedings of the National Academy of Sciences 101(51):17622-17627.
  • Screaton, R.A., Conkright, M.D., Katoh, Y., Best, J.L., Canettieri, G., Jeffries, S., Guzman, E., Niessen, S., Yates III, J.R., Takemori, H., Okamoto, M., and Montminy, M. (2004). “A Latent Cytoplasmic CREB Coactivator Functions as a Calcium and cAMP Sensitive Coincidence Detector.” Cell 119(1):61-74.
  • Best, J.L., Ganiatsas, S., Agarwal, S., Changou, A., Salomoni, P., Shirihai, O., Meluh, P.B., Pandolfi, P.P., and Zon, L.I. (2002). “SUMO-1 Protease-1 Regulates Gene Transcription though PML.” Molecular Cell 10:843-855.
  • Ross, S., Best, J.L., Zon, L.I., and Gill, G. (2002). “SUMO-1 Modification Represses Sp3 Transcriptional Activation and Modulates Its Subnuclear Localization.” Molecular Cell 10:831-842.
  • Pierce, J.W., Schoeleneber, R., Jesmok, G., Best, J., Moore, S.A., Collins, T., and Gerritson, M.A. (1997). “Novel Inhibitors of Cytokine-induced IB Phosphorylation and Endothelial Cell Adhesion Molecule Expression Show Anti-inflammatory Effects in Vivo.” The Journal of Biological Chemistry 272(34):21096-21103.
  • Read, M.A., Whitley, M.A., Gupta, S., Pierce, J.W., Best, J., Davis, R.J., and Collins, T. (1997). “Tumor Necrosis Factor -induced E-selectin Expression is Activated by the Nuclear Factor-B and c-Jun N-terminal Kinase/p38 Mitogen-activated Protein Kinase Pathways.” The Journal of Biological Chemistry 272(5):2753-2761.