In the era of precision oncology, the integration of artifical intelligence (AI) is not just beneficial; it’s essential. AI enhances our ability to analyze vast amounts of data allowing for more accurate and tailored treatments. This technology brings clarity to complexity, empowering clinicians to make informed, data-driven decisions that lead to better patient outcomes. Moreover, by identifying patterns that may go unnoticed by the human eye, AI helps us to not only predict cancer progression, but also to minimize adverse effects.
Dr. Douglas B. Flora* wrote an interesting article “Top 10 AI in Precision Oncology Stories of 2024” (AI Report) that highlights the progress and potential of AI-enabled medicine in precision oncology.
10. Automated Pathology Analysis
In 2024, major health care centers used AI-powered digital pathology to accelerate diagnosis speeds and improve accuracy. In addition to speeding up patient care, the technology brings world-class diagnostic capabilities to many underserved communities. Dr. Flora predicts that by next year, system integration with genomic data may create a diagnostic picture for increasingly personalized treatment plans.
9. Molecular Response Prediction
AI has improved the ability to analyze complex molecular data such as genomics, proteomics, and metabolomics, to predict how a tumor will respond to different treatments before therapy begins. With this information, the best treatment is selected for therapy for better patient outcomes. Increasingly, some researchers are integrating this technology to time monitor therapy and inform clinical trial design.
8. Federated Learning Networks
This technology allows health care providers from different cancer centers to share insights without sharing sensitive patient data. It is reported that a “breakthrough study using this approach identified five new biomarkers for rare pediatric cancers by analyzing data from 65 institutions across three continents while maintaining strict patient privacy standards.”
7. AI-Enhanced Clinical Trial Matching
In 2024, AI systems transformed matching patients with clinical trials by automatically scanning patient records, genetic profiles, and trial databases to identify real-time matches. Dr. Flora reports that while only 3–5% of adult cancer patients typically participate in clinical trials, centers using AI matching systems report an increase in participation to 15–20%.
6. Treatment Response and Toxicity Prediction
Adverse reactions to treatments can be predicted before they happen by analyzing multiple patient data points, such as lab values, genetic markers, and patient symptoms. Cancer Centers using these AI systems reported 30–40% reductions in severe adverse events and a 25% decrease in emergency department visits. “One major cancer center documented $3.2 million in savings from prevented complications in just 6 months.”
5. Precision Radiomics
This technology can extract thousands of quantitative features from standard imaging studies to predict tumor behavior and treatment response. In 2024, AI-powered radiomics predicted immunotherapy response with 89% accuracy, an increase of 29% over conventional methods, thereby sparing patients from ineffective treatments and quickly identifying those who will benefit most.
4. Clinical Decision Support
AI-powered clinical decision support (CDS) became in 2024 collect and analyze massive amounts of information like technical journals and physician notes to offer context-aware insights based on real-world evidence and patient-specific factors. This technology promises to democratize expertise for communities that may not have access to large medical centers.
3. Reducing Physician Administrative Burdens
Physicians are spending more time on administrative duties like documentation. AI systems can now not only record conversations, they can extract meaningful insights and generate clinical notes in real time.
2. Multimodal Early Detection
These systems collect and analyze data types, e.g., imaging, blood-based biomarkers, genomic signatures, and lab values, to detect cancer at its earliest, most treatable stages. “The numbers from 2024’s multimodal AI studies are staggering: detection rates improved by 65% for certain cancer types, with false-positive rates dropping by 40%. “One large-scale study found that AI-enhanced screening could identify pancreatic cancer an average of 17 months earlier than conventional methods-potentially transforming outcomes for one of our most challenging cancers.” AI Report.
1. AI’s Quantum Leap in Understanding Cancer’s Machinery
In 2024, the Novel Prize in Chemistry was awarded to DeepMind’s John Jumper and Demis Hassabis for AlphaFold, and to David Baker of the University of Washington for their pioneering work in protein structure prediction. This technology can be applied to discover new drug targets for novel cancer therapies.
Some closing thoughts….
The rapid advancement of AI in personalized oncology is truly remarkable. With its ability to detect early-stage cancers, patients are receiving timely intervention that can save lives. Additionally, the technology can reduce treatment toxicity, allowing for a more tailored approach that enhances patients’ quality of life. What is even more impressive is how AI democratizes access to world-class expertise, ensuring that cutting-edge treatment options are available to all. This is not just a breakthrough, it is a revolution in health care.
*Douglas B. Flora, MD, is Editor-in-Chief of AI in Precision Oncology.
I am struck by how 2024 became our GPS moment in cancer care—this year marked not just incremental improvements but fundamental shifts in detecting, understanding, and treating cancer. From automated pathology revolutionizing laboratory workflow to a Nobel Prize-winning breakthrough redefining drug discovery, these advances are rewriting the rules of what is possible. This is an ideal time to look back at the past year and to celebrate the remarkable progress being made.
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Douglas B. Flora, M.D., “Top 10 AI in Precision Oncology Stories of 2024” in Inside Precision Medicine, originally published in the February 2025 issue of AI in Precision Oncology.
