Increasingly, the development of new pharmaceuticals utilize genetic information to stratify patient subpopulations and/or predict efficacy and adverse events – the development paradigm of personalized medicine. A recent report by Thomas Reuters (“Spotlight On … Personalized Medicine, A Pharma Matters Report," the “Report”) summarizes the technical, regulatory and economic challenges the pharmaceutical industry faces as they move from the traditional drug development model to a personalized approach. Historically, the development of new molecular entities rely on developing drugs with annual sales over $1.0 billion. In contrast, personalized medicine will develop drugs and therapies targeted to smaller patient populations with significantly reduced annual sales. The Report also underscores the benefits of personalized medicine and highlights progress the pharmaceutical industry has made toward providing targeted therapies.
Benefits and Progress in Personalized Medicine
Personalized Medicine Today
The Report lists that over 50 drugs having a predetermined genetic marker are in development. Quoting a study conducted by the Tufts Center for the Study of Drug Development, the Report notes that more than 90 percent of pharmaceutical companies now utilize at least some genomic-derived targets in their drug discovery program.
In addition, the Report lists several notable collaborative efforts to develop personalized therapies, but cautioned that it is unclear from the available information if the development of a targeted therapy drove the deals. However, the Report notes an emerging trend to re-purpose fully-launched therapies as personalized products to cut development costs and improve efficiency.